Molecular & Structural Biology

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Study provides first structural glimpse of circadian clock's molecular machinery

Scientists have long known that circadian clocks- biochemical oscillators that control physiology, metabolism and behavior on a roughly 24-hour cycle- are present in all forms of life, including animals, plants, fungi and some types of bacteria. However, the molecular mechanisms that "run" these systems remain largely unknown.

7 Sep 2017

Four year $1.4 million Air Force grant supports WVU biologists to explore moths’ olfactory systems

As humans walk and talk, we sense our own movements or sounds. Yet, we can distinguish our actions from everything else in our environment that affects our senses.

7 Sep 2017

Natural compound produced by honeybees could become basis for new antibiotics

An antimicrobial compound made by honeybees could become the basis for new antibiotics, according to new research at the University of Illinois at Chicago.

7 Sep 2017

Researchers harness lipid nanodiscs to produce hydrogen fuel

A U.S.-based team of researchers featuring MIPT scientists has assembled a nanoscale biological structure capable of producing hydrogen from water using light.

6 Sep 2017

Study reveals etosis phenomenon in human blood monocytes

A recent study published online in the Journal of Leukocyte Biology found the first clear demonstration of etosis in human blood monocytes, a type of immune cell.

1 Sep 2017

Scientists make breakthrough in understanding the powerhouse of human cells

Scientists have made a breakthrough in understanding how mitochondria - the "powerhouses" of human cells - are made.

31 Aug 2017

UAB researchers reveal key role for RSF1 protein in silencing genes

A fertilized human egg develops into multiple tissues, organs and about 200 distinct cell types. Each cell type has the same genes, but they are expressed differently during development and in mature cells.

31 Aug 2017

New discovery reveals gut bacteria and human cells speak the same chemical language

We have a symbiotic relationship with the trillions of bacteria that live in our bodies--they help us, we help them. It turns out that they even speak the same language.

30 Aug 2017

Researchers develop new approach to efficiently produce versatile antibody therapies

A group of researchers has developed an approach to efficiently produce antibodies that can bind to two different target molecules simultaneously, a long-desired innovation in the field of cancer immunotherapy.

29 Aug 2017

Research reveals LEGO-like stacking of protein complexes

When hemoglobin undergoes just one mutation, the protein complexes stick to one another, stacking like LEGO blocks to form long, stiff filaments.

29 Aug 2017

Study provides better understanding of how estrogen regulates gene expression

Estrogen hormones regulate gene expression. They achieve this by first binding to estrogen receptor in the cell nucleus, which triggers the recruitment of different molecules called coactivators in specific order.

24 Aug 2017

Research shows how glutamine plays role in regulating cellular differentiation programs

The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs have to be turned on or off.

17 Aug 2017

Cryo-electron microscopy advances by Thermo Fisher Scientific drives structural biology research

Thermo Fisher Scientific, the world leader in serving science, has extended its leadership in cryo-electron microscopy (cryo-EM) with the introduction of two new instruments: the Thermo Scientific Krios G3i and the Thermo Scientific Glacios cryo-transmission electron microscopes (cryo-TEMs).

From Thermo Fisher Scientific Inc. 9 Aug 2017

Vanderbilt researchers unravel how bacterial toxin prevents DNA replication

One of the most potent toxins known acts by welding the two strands of the famous double helix together in a unique fashion which foils the standard repair mechanisms cells use to protect their DNA.

2 Aug 2017

DNA-sensing mechanism of innate immune system controls cellular senescence

Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due to the cell growing "old".

31 Jul 2017

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Sixty-four years ago, James Watson and Francis Crick described the now-iconic double helix structure of DNA.

29 Jul 2017

Structure of protein in salmon virus could inform strategies to treat flu in humans

The structure of a protein key to the survival and spread of a virus that affects salmon could inform strategies to treat the flu in humans, according to scientists at Rice University.

28 Jul 2017

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Using an array of modern biochemical and structural biology techniques, researchers from Boston University School of Medicine have begun to unravel the mystery of how acidity influences a small protein called serum amyloid A (SAA).

28 Jul 2017

Molecule plays essential role in establishing proper neural wiring in the cerebellum

Researchers at Hokkaido University have found that the molecule "L-gutamate/L-aspartate transporter" (GLAST) plays an essential role in establishing and maintaining proper neural wiring of Purkinje cells in the cerebellum.

28 Jul 2017

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

How can six and half feet of DNA be folded into the tiny nucleus of a cell? Researchers funded by the National Institutes of Health have developed a new imaging method that visualizes a very different DNA structure, featuring small folds of DNA in close proximity.

27 Jul 2017

Molecular & Structural Biology

Study provides first structural glimpse of circadian clock's molecular machinery

Four year $1.4 million Air Force grant supports WVU biologists to explore moths’ olfactory systems

Natural compound produced by honeybees could become basis for new antibiotics

Researchers harness lipid nanodiscs to produce hydrogen fuel

Study reveals etosis phenomenon in human blood monocytes

Scientists make breakthrough in understanding the powerhouse of human cells

UAB researchers reveal key role for RSF1 protein in silencing genes

New discovery reveals gut bacteria and human cells speak the same chemical language

Researchers develop new approach to efficiently produce versatile antibody therapies

Research reveals LEGO-like stacking of protein complexes

Study provides better understanding of how estrogen regulates gene expression

Research shows how glutamine plays role in regulating cellular differentiation programs

Cryo-electron microscopy advances by Thermo Fisher Scientific drives structural biology research

Vanderbilt researchers unravel how bacterial toxin prevents DNA replication

DNA-sensing mechanism of innate immune system controls cellular senescence

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Structure of protein in salmon virus could inform strategies to treat flu in humans

Researchers unravel how acidic conditions favor protein misfolding in deadly diseases

Molecule plays essential role in establishing proper neural wiring in the cerebellum

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

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